Description
Chemical Identity
| Property | Specification |
|---|---|
| Chemical name | N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide |
| Molecular formula | C₂₀H₂₁FN₄O₂ |
| Molecular weight | 368.4 g mol⁻¹ |
| Purity (HPLC) | ≥ 98 % |
| Appearance | Off-white to beige crystalline solid |
| CAS | 1185282-01-2 |
Potency & Pharmacological Profile
AB-FUBINACA exhibits nanomolar-range affinity at the CB₁ receptor and acts as a full agonist in cell-based assays. Trace-level concentrations are typically sufficient for receptor activation studies. It provides a consistent benchmark for evaluating new cannabinoid analogues and understanding desensitization dynamics in receptor systems.
Laboratory Handling & Storage
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Handling: Use only in certified chemical laboratories under fume-hood ventilation with gloves and protective eyewear.
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Solubility: Readily soluble in methanol, ethanol, acetone, and DMSO; limited aqueous solubility.
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Storage: Preserve at –20 °C in sealed amber glass, under desiccated conditions. Avoid light and humidity exposure.
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Stability: Stable up to 12 months when kept cold, dry, and dark.
Research Precautions
Because of its exceptional potency, AB-FUBINACA should be weighed on microbalances (≤ 0.1 mg precision). Avoid aerosol formation or direct contact. Dispose of all residues according to local hazardous-chemical waste regulations. Not for human or veterinary use.
Relevance to Health-Science Studies
This compound has proven useful as a tool in:
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Characterizing cannabinoid receptor signaling pathways
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Developing detection standards for forensic and clinical laboratories
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Investigating molecular mechanisms of receptor desensitization and tolerance
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Advancing computational models for endocannabinoid system pharmacology
Reviews
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